Brain function deteriorates rapidly when it is deprived of oxygen. This can occur at extremely high altitudes or during acute head trauma encountered in sports like football, Alpine skiing and soccer. Creatine supplements protect the brain from low oxygen environments— according to a study by a research team from New Zealand. Researchers subjected healthy adults to 10 percent oxygen for 90 minutes, which severely impaired brain function. Normal oxygen levels are slightly less than 21 percent. Pretreatment with creatine for seven days protected the brain against the effects of low oxygen. It is unknown whether creatine would be a good supplement for preventing brain injury in athletes.
Source: Journal Neuroscience, 35: 1773-1780, 2015