Maximizing Quad Size and Strength

Follow These 3 Golden Rules

Best Squat Workout for Strength: Heavy Weight Versus Lighter Loads to Failure

The squat is the best leg-developing exercise because of its remarkable capacity to simultaneously activate most of the major muscle groups within the lower body, generating tremendous muscle growth and strength. While all of the muscle-building capabilities from squatting are fantastic, there has been some uncertainty about what training protocol elicits maximum strength gains while performing the squat. One of the more complex, yet seemingly simple, questions asked when assessing the capacity of a certain training approach to build strength is simply how many repetitions should be performed and at what intensity level.

Maximizing Quad Size and Strength

1. Standard Training Intensity for Size or Strength

The typical training approach for maximal squat strength utilizes approximately 80 to 90 percent of your one-repetition maximum (1RM) within the repetition range of two to five, while using 75 to 85 percent of your 1RM within the repetition range four to 12 is usually employed to preferentially stimulate muscle hypertrophy. Heavier weights augment strength principally by inducing greater neuromuscular activation of fast-twitch muscle fibers, which contract more quickly than slow-twitch muscle fibers, producing more power.

The increased activation of fast-twitch muscle fibers from high-intensity training ultimately leads to greater strength gains. On the other hand, higher-volume training more specifically amplifies muscle growth, in large part by increasing muscle time under tension, which increases metabolic stress— encouraging muscle hypertrophy.

Several studies highlight the aforementioned differences in training outcomes, pointing out that training prescriptions for hypertrophy differ considerably from those that preferentially boost strength.1 In fact, as a proof of principle, most powerlifters— whose primary goal is to get stronger— characteristically perform high-intensity training using 85 percent to 95 percent of their 1RM for three to five repetitions, while most bodybuilders utilize lighter weights in the 75 percent to 85 percent range of their 1RM, usually for eight to 12 repetitions.

2. Greater Muscle Contraction Equals Greater Strength

A key element required for improved strength arises from an enhanced capacity to swiftly activate muscular contraction. It has been well documented that lifting heavier loads increases the ability to recruit, or activate, muscular contraction, demonstrating one of the pivotal mechanisms triggered by heavier loads that more effectively promotes strength gains.2,3 On the contrary, other studies have also shown increased levels of muscle activity can be caused while using lighter weights and more repetitions.4,5

The rise in muscle activity triggered while using lighter weights with more repetitions has been attributed to the sequential activation of additional muscle tissue that occurs in order to sustain muscular contraction throughout the entire lift as muscular fatigue accumulates. As a result, the larger amount of muscle activity brought on by the use of lighter loads and higher repetitions could potentially lead to comparable gains in strength that are seen when using heavier weight. However, the relative increase in muscle activity when performing more repetitions with lighter resistance is still unclear, when compared to the use of heavier resistance. Thus, the ability of this training approach to boost strength has remained undefined.

Since muscular fatigue brought on by higher-repetition training induces the activation of additional muscle tissue in a compensatory way, perhaps training techniques that pre-exhaust the muscle more extensively— such as drop sets, which use heavier weight to induce greater muscular fatigue, followed immediately by lighter-weight training to failure— may trigger an even larger amount of muscle activation, ultimately generating more muscle activity that further augments strength improvement.

Maximizing Quad Size and Strength

3. High-Intensity Training Prevails

Researchers wanted to investigate whether higher-repetition training with lighter weights alone could induce similar, or greater muscular activity, than heavy resistance training can. To this end, a study by Looney et al.6 looked at the muscle activity of two major muscles within the upper leg, the vastus lateralis and the vastus medialis, while 10 young men with extensive training experience performed the squat to their maximum amount of repetitions, with an increasing load level of 50, 70 or 90 percent of their respective 1RM. The results demonstrated that muscle activity in both muscle groups was significantly greater when performing 90 percent of their 1RM to muscular failure, compared to when they performed the squat at 50 and 70 percent of their 1RM, also to muscular failure. Training at 70 percent of their 1RM resulted in significantly greater recruitment than training at 50 percent of their 1RM.

To further investigate whether higher-repetition training with lighter weights combined with drop sets could induce muscular activity comparable to heavy resistance training alone, Looney et al. looked at the muscle activity of the same upper leg muscles, while subjects performed the maximum amount of repetitions in the squat with a light load (50 percent of their 1RM) right after performing the squat with 70 and 90 percent of their 1RM to failure. This was done with no rest between any of the sets, to maximize muscular fatigue and hopefully induce greater muscular activity. The data showed that using the drop set method to pre-fatigue the muscle did not increase muscle activity above the levels seen when simply performing a set to failure using the same 50 percent of the 1RM.

Altogether, these results confirm the previously held belief that greater muscle activity occurs with use of heavier weights, and the addition of pre-fatigue methods such as drop set does not lead to greater muscle activity during subsequent low-intensity training.


Heavy resistance training alone is still one of the most effective ways to trigger muscle activity and bolster strength. Moreover, despite other training methods that successfully incorporate the use of light weights while bolstering considerable gains in strength, the use of pre-exhaust training methods at high intensity levels, combined with high-repetition training at light loads, does not produce the desired effect of increased muscular contractility— meaning this approach will likely be unsuccessful at boosting any significant amount of muscular strength.

1. Masuda K, Choi JY, et al. Maintenance of myoglobin concentration in human skeletal muscle after heavy resistance training. Eur J Appl Physiol Occup Physiol 1999;79, 347-352.
2. Duchateau J and Hainaut K. Training effects of sub-maximal electrostimulation in a human muscle. Med Sci Sports Exerc 1988;20, 99-104.
3. Pucci AR, Griffin L and Cafarelli E. Maximal motor unit firing rates during isometric resistance training in men. Exp Physiol 2006;91, 171-178.
4. Hassani A, Patikas D, et al. Agonist and antagonist muscle activation during maximal and submaximal isokinetic fatigue tests of the knee extensors. J Electromyogr Kinesiol 2006;16, 661-668.
5. Pincivero DM, Aldworth C, et al. Quadriceps-hamstring EMG activity during functional, closed kinetic chain exercise to fatigue. Eur J Appl Physiol 2000;81, 504-509.
6. Looney DP, Kraemer WJ, et al. Electromyographical and Perceptual Responses to Different Resistance Intensities in a Squat Protocol: Does Performing Sets to Failure With Light Loads Recruit More Motor Units? J Strength Cond Res 2015. [Epub, ahead of print]

For most of Michael Rudolph’s career he has been engrossed in the exercise world as either an athlete (he played college football at Hofstra University), personal trainer or as a Research Scientist (he earned a B.Sc. in Exercise Science at Hofstra University and a Ph.D. in Biochemistry and Molecular Biology from Stony Brook University). After earning his Ph.D., Michael investigated the molecular biology of exercise as a fellow at Harvard Medical School and Columbia University for over eight years. That research contributed seminally to understanding the function of the incredibly important cellular energy sensor AMPK— leading to numerous publications in peer-reviewed journals including the journal Nature. Michael is currently a scientist working at the New York Structural Biology Center doing contract work for the Department of Defense on a project involving national security.