Some Antidepressant Drugs Suppress Sexual Function More Than Others

Depression is a serious disorder that destroys the quality of life and can lead to suicide.

Antidepressant drugs (selective serotonin reuptake inhibitors, SSRIs) are lifesavers for many people suffering from this disorder. Unfortunately, these drugs can cause sexual problems such as delayed ejaculation, impaired orgasms, decreased sexual desire and arousal, decreased sperm production, slowed sperm transport, damaged sperm cell membranes and damage to the DNA controlling sperm production. Some SSRIs impair sexual performance more than others— according to a study led by Alireza Zahiroddin from Shahid Beheshti University of Medical Sciences in Iran. Researchers found that Wellbutrin (bupropion) caused more sexual problems than Symmetrel (amantadine) during a four-week clinical study. Both drugs, however, impaired sexual function. These drugs have some positive effects on sexual performance. Many studies found that SSRIs improve premature ejaculation— the most common sexual problem in young men. (Iranian Red Crescent Medical Journal, 17(12): e24998, 2015)

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