Calcium Salt HMB Shows Best Bioavailability

HMB is a breakdown product of the amino acid leucine. Most studies have found that HMB increased muscle mass, strength and physical performance. It works by increasing protein synthesis and preventing protein breakdown. Supplements containing HMB sometimes contain either the calcium salt or free acid form of the compound. A study on rats from Abbott Nutrition Research and Development found that the calcium salt variety of HMB was the most biologically available form of the compound. The animals were given oral supplements in three different doses. HMB is an effective supplement, but some forms work better than others. (Journal Nutrition, 144: 1549-1555, 2014)

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