Intense weight training causes stiffness in the arteries. While the effects are temporary, long-term strength training could cause changes to the arteries that could result in hypertension (high blood pressure) and increased stress on the heart. Creatine monohydrate supplements might protect the blood vessels and heart from the negative effects of weight training. A Florida State University study led by Marcos Sanchez-Gonzales found that creatine supplements (10 grams per day for three weeks) reduced arterial stiffness and blood pressure responses to weight training. Weight training is a healthy form of exercise for adults that increases metabolic health and promotes longevity. This study showed that creatine monohydrate supplements might prevent some of the negative effects of weight training.
Source: (European Journal of Applied Physiology, 111:1965-1971)